Main Article Content
Objective: To determine the predictive factors for the occurrence of tuberculosis (TB) in adults infected with the human immunodeficiency virus (HIV) during the first 6 months of antiretroviral therapy (ART) in Kisangani.
Methods: A case-control study was carried out during the period from January 1, 2017 to December 31, 2018. Clinical data were collected retrospectively from patients receiving antiretroviral therapy in the city of Kisangani. Of a total of 1,161 HIV-infected patients included in this study, 58 of them developed TB. The diagnosis of tuberculosis was made on the presence of Acid-Alcohol-Resistant Bacile (BAAR) on at least one biological sample or on the basis of a bundle of clinical and paraclinical arguments. This test is done during the first six months of initiating anti retroviral therapy (ART). Predictive factors for the onset of TB in these patients on antiretroviral therapy were identified using logistic regression analysis.
Results: After multivariate analysis, the independent factors associated with the onset of TB were: being married (OR = 4.456; 95% CI: 1.061-18.713), residence in the town of Tshopo (OR = 7.04; 95% CI: 1.168-42.47) as well as stages 3 and 4 of AIDS disease (OR = 29 95% CI: 4.563-184.872 and OR = 50.8 95% CI: 3.971-680.995).
Conclusion: The results found by this study highlight the need for active TB testing in HIV-infected individuals. Particular emphasis should be placed on the category of patients on antiretroviral therapy who have one of the independent factors for the onset of TB.
Gupta A, Wood R, Kaplan R, et al. Tuberculosis incidence rates during 8 years of follow-up of an antirétroviral treatment cohort in south Africa: Comparison with rates in the community. Plos One; 2012.
Melkamu H, Seyoum B, Dessie Y. Determinants of tuberculosis infection among adult HIV positives attending clinical care in western Ethiopia: A case-control study, AIDS Research and Treatment. 2013;7.
[Article ID: 279876]
Poda A, Hema A, Zoungrana J, KaboraF, et al. Predictors of the occurrence of tuberculosis in adults infected with HIV at the Bobo Dioulosso day hospital, Burkina Faso; 2014.
Yihun Mulugeta, Alemu et al. Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia: A multicentre case control study; 2014.
Daniel WG, Simon CM, Igembe N, et al. Prevalence and risk factors of active TB among adults HIV patients receiving ART in Northwestern Tanzania; 2018.
OMS. Key interventions to reduce the impact of TB on people living with HIV, OMS; 2016.
Abgrall. Pascal Del Giudice, Giovanna Melica, et al. Tuberculose associé au VIH: Incidence et facteurs de risque en France ; 2008.
Brennan AT, Bonawitz K, Schnippel, et al. Incident tuberculosis in HIV-positive children, adolescents and adults on antiretroviral therapy in South Africa; 2016.
Liu E, Makubi A, Drainetal P, et al. Tuberculosis incidence rate and risk factors among HIV-infected adults with access to antiretroviral therapy. AIDS. 2015;29(11):1391–1399.
Martin-Echevarria E, Serrano-Villar S, Sainz T, et al. Development of tuberculosis human immunodeﬁciency virus infected patients receiving antiretroviral therapy. International Journal of Tuberculosis and Lung Disease. 2014;18(9):1080– 1084.
Lawn SD, Wood R, De Cock KM, Kranzer K, Lewis JJ, Churchyard GJ. Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources. The Lancet Infectious Diseases. 2010;10(7):489–498.
Melkamu H, Seyoum B, Dessie Y. Determinants of tuberculosis infection among adult HIV positives attending clinical care in western Ethiopia: A case-control study. AIDS Research and Treatment. 2013;7.
[Article ID: 279876]