COVID-19 Vaccination Concerns: Perspectives of Youths in a Developing Nation's Context

Ugochukwu Samuel Aguwa *

Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.

Izuchukwu Azuka Okafor

Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria and Department of Obstetrics and Gynecology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria and Pan African University of Life and Earth Science Institute, University of Ibadan, Ibadan, Nigeria. d Birmingham Business School, University of Birmingham, UK.

Echezona Ejike Udokanma

Birmingham Business School, University of Birmingham, UK.

Ikechukwu Jude Okolie

Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.

Okonkwo David Izuchukwu

Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.

Felix Ovie Ogbo

Department of Anatomy, Faculty of Basic Medical Sciences, Gregory University, Uturu, Abia State, Nigeria.

Chioma Dorothy Nwosu

Abia State University, Uturu, Nigeria.

Adline Uchechi Aguwa

Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

Background: Vaccine programmes' success lies in the acceptability and understanding of vaccine concerns among diverse population groups. This study investigates the covid-19 vaccination concerns among Nigerian youths.

Methods: We conducted a cross-sectional study of 631 youths (343 females and 270 males) between 15-44 years who were randomly recruited online and offline from the six geo-political regions of Nigeria. The questionnaire was administered between 10 February and 15 March 2021. SPSS (Chi-square and Cramer's V Statistic) was used to determine the association (p<0.05)between covid-19 vaccination concerns and participants' demographic characteristics.

Results: Among the 12 identified covid-19 vaccination concerns, side-effects (p=0.037), not necessary (p=0.007), negative reaction to vaccines (p=0.026) and assumed non-exposure to covid-19 patients (p=0.004),, were statistically associated with gender. For age, efficacy doubt (p=0.023), political/economic construct (p=0.023), family disapproval (p=0.018), and non-exposure to covid-19 patients (p=0.000) were statistically significant. Efficacy doubt (p=0.029) and the vaccine is a hoax (p=0.020) were associated with marital status. Side effect (p=0.182), a mere human experiment (p=0.777), doubt on efficacy (p=0.305), not necessary (p=0.457), political/economic construct (p=0.673), negative reaction to vaccine (p=0.162), and the vaccine may not be affordable (p=0.506) were not associated with the occupation. For the level of education, side effects (p=0.140), a mere human experiment (p=0.580), efficacy doubt (p=0.243), and negative reaction to the vaccine (p=0.386).

Conclusion: Amongst youths in developing nations, especially in institutions of learning, health promotion and vaccine advocacy strategies should be intensified. The strategies should incorporate reinstating trust in vaccine efficacy and education and target youths and their family health decision-makers.  

Keywords: COVID-19 vaccine, coronavirus, vaccine concerns, vaccine advocacy, developing nations, Nigeria


How to Cite

Samuel Aguwa, U., Azuka Okafor, I., Ejike Udokanma, E., Jude Okolie, I., David Izuchukwu, O., Ovie Ogbo, F., Dorothy Nwosu, C., & Uchechi Aguwa, A. (2023). COVID-19 Vaccination Concerns: Perspectives of Youths in a Developing Nation’s Context. Asian Journal of Research in Infectious Diseases, 12(2), 7–21. https://doi.org/10.9734/ajrid/2023/v12i2238


References

Ioannidis J. Reconciling estimates of global spread and infection fatality rates of COVID-19: An overview of systematic evaluations. European Journal of Clinical Investigation. 2021;51(5):13554.

Available: https://doi.org/10.1111/eci.13554

Ioannidis, JPA. Global perspective of COVID-19 epidemiology for a full-cycle pandemic. Eur J Clin Invest. 2020;00: e13423.

Available:https://doi.org/10.1111/eci.13423

Le TT, Cramer JP, Chen R, Mayhew S. Evolution of the COVID-19 vaccine development landscape. Nat Rev Drug Discov. 2020;19:667-8.

WHO (2021) WHO lists additional COVID-19 vaccine for emergency use and issues interim policy recommendations.WHO lists additional COVID-19 vaccine for emergency use and issues interim policy recommendations(Accessed 15/07/2021).

Razai SM, Chaudhry UAR, DoerholtK, Bauld L, Majeed A. Covid-19 vaccination hesitancy. BMJ 2021;373:n1138.

DOI: https://doi.org/10.1136/bmj.n1138

Aguwa US, Okafor IA, Okolie IJ, Udokanma EE, Ogbo FO. Covid-19 Vaccination Amongst Nigerian Youths: An Anticipated Hesitancy and Advocacy Strategy. Journal of Health Services Research & Policy (Under peer-review)

Robinson ED, Wilson P, Eleki BJ, Wonodi W. Knowledge, acceptance, and hesitancy of COVID-19 vaccine among healthcare workers in Nigeria. MGM J Med Sci 2021;8:102-10.

Al-Mistarehi A, Kheirallah KA, Yassin A, et al. Determinants of the willingness of the general population to get vaccinated against COVID-19 in a developing country. Clin Exp Vaccine Res 2021;10:171- 182

Available:https://doi.org/10.7774/cevr.2021.10.2.171

Lamptey E, Serwaa D, Appiah AB. A nationwide survey of the potential acceptance and determinants of COVID-19 vaccines in Ghana. Clin Exp Vaccine Res 2021;10:183-190.

Available:https://doi.org/10.7774/cevr.2021.10.2.183

Jegede AS. What led to the Nigerian boycott of the polio vaccination campaign? PLoS Medicine. 2007;4(3): e73.

Holzmann H, and Wiedermann U. Mandatory vaccination: suited to enhance vaccination coverage in Europe? Euro Surveill. 2019;24:1900376.

African Youth Charter. African Union Charter: A Strategic Framework for Youth Empowerment and Development Activities.

Available: https://esaro.unfpa.org/sites/default/files/pub-pdf/CHARTER_English.pdf [Accessed 18/07/ 2021].

Nigeria Data Portal. Nigeria Population by Age and Sex - Nigeria Data Portal (opendataforafrica.org) (Accessed 18/07/2021).

Yamane T. Statistics, An Introductory Analysis, 2nd Ed., New York: Harper and Row; 1967.

Lazarus JV, Ratzan SC, Palayew A, et al. A global survey of potential acceptance of a COVID-19vaccine. Nature Medicine 2021;27:225–228.

Available: https://doi.org/10.1038/s41591-020-1124-9.

Attanasi G, Maffioletti A, Shalukhina T, Bel C, Cherikh F. Gender Differences in the Impact of COVID-19 Lockdown on Potentially Addictive Behaviors: An Emotion-Mediated Analysis. Frontiers in Psychology. 2021;12:703897-.

Magon A, Arrigoni C, Graffigna G, Barello S, Moia M, Palareti G, Caruso R. The effect of health literacy on vaccine hesitancy among Italian anticoagulated population during COVID-19 pandemic: the moderating role of health engagement. Human Vaccines & Immunotherapeutics. 2021:1-6.

Inko-Tariah DC. Assessment of Literacy and Numeracy Levels of Junior Secondary School Students in Rivers State of Nigeria. Assessment. 2014;5(19).

Fayehun F, Isiugo-Abanihe U. EndSARS: How Nigeria can tap into its youthful population. The Conversation. Retrieved 2022, from https://theconversation. com/endsars-how-nigeriacan-tap-into-its-youthful-population. 2020;148319.

Hall R. 2020. Anti-vaccination movement could derail fight against coronavirus, experts warn. Independent, 25 March.

Available: https://www.independent.co.uk/news/world/americas/coronavirus-vaccine-antivaxxer-donald-trump-a9426151.html

Lane S, MacDonald NE, Marti M, Dumolard L. Vaccine hesitancy around the globe: analysis of three years of WHO/UNICEF Joint Reporting Form data-2015–2017. Vaccine. 2018;36:3861–67.

MacDonald NE.. Vaccine hesitancy: definition, scope and determinants. Vaccine. 2015;33:4161–64.

WHO (World Health Organ.). 2019. Ten threats to global health in 2019. World Health Organization News, 21 March.

Available:https://www.who.int/vietnam/news/feature-stories/detail/ten-threats-toglobal-health-in-2019.

Dubé È, Ward JK, Verger P, MacDonald NE. Vaccine hesitancy, acceptance, and anti-vaccination: trends and future prospects for public health. Annu Rev Public Health. 2021;42(1):175-91.

Trump D. President Donald Trump Speaks On Immigration With Angel Families. Speech, White House, Washington, DC; 2018.

Kelland K. Bill Gates has a warning about population growth. InWorld Economic Forum; 2018.

Kulandairaj AJ. Impact of social media on the lifestyle of youth. International Journal of Technical Research and Applications. 2014;2(8):22-8.

Available:https://www.thecable.ng/nigeria-missing-as-uk-recognises-covid-vaccine-certificates-from-over-50-countries. September18,2021(https://twitter.com/agayiba/status/1439217903614799875?failedScript=vendors~main).

Ozawa S, Stack ML. Public trust and vaccine acceptance-international perspectives. Human vaccines & immunotherapeutics. 2013;9(8):1774-8.

Centers for Disease Control and Prevention (CDC. Thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service. MMWR. Morbidity and mortality weekly report. 1999;48(26):563-5.

Geier MR, Geier DA. Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. Experimental biology and medicine. 2003;228 (6):660-4.

Santibanez TA, Nguyen KH, Greby SM, Fisher A, Scanlon P, Bhatt A, Srivastav A, Singleton JA. Parental vaccine hesitancy and childhood influenza vaccination. Pediatrics. 2020;144-146.

Euser S, Kroese FM, Derks M, de Bruin M. Understanding COVID-19 vaccination willingness among youth: A survey study in the Netherlands. Vaccine. 2022;40(6):833-6.

Merten S, Schaetti C, Manianga C, Lapika B, Chaignat CL, Hutubessy R, Weiss MG. Local perceptions of cholera and anticipated vaccine acceptance in Katanga province, Democratic Republic of Congo. BMC public health. 2013;13(1):1-2.

Eniade OD, Olarinmoye A, Otovwe A, Akintunde FE, Okedare OO, Aniyeloye AO. Willingness to accept COVID-19 vaccine and its determinants among Nigeria citizens: a web-based cross-sectional study. J Adv Med Med Res. 2021;33(8):13-22.