Variation of Biological and Biochemical Parameters in Patients Receiving Antiretroviral Treatment at the Maradi Regional Hospital during 2021-2022
Harouna Amadou Mahaman Laouali
Faculty of Health Sciences, Dan Dicko Dankoulodo University of Marad, Niger.
Abdoulaye Ousmane
Faculty of Health Sciences, Dan Dicko Dankoulodo University of Marad, Niger.
Amadou Oumarou
Faculty of Health Sciences, Dan Dicko Dankoulodo University of Marad, Niger.
Ibrahim Mamadou Abdoul Kadir *
Dosso Regional Hospital, Niger.
Gado Amadou Mahamadou
Niamey National Hospital, Niger.
Boureima Hassane
Faculty of Health Sciences, Dan Dicko Dankoulodo University of Marad, Niger.
Abdou Adamou Rachidou
Maradi Regional Hospital, Niger.
Moussa Saley Sahada
Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger.
Kabirou Amoussa Abdoul Aziz
Maradi Regional Hospital, Niger.
Harouna Moussa
Dosso Regional Hospital, Niger.
Doutchi Mahamadou
Faculty of Health Sciences, André Salifou University, Zinder, Niger.
*Author to whom correspondence should be addressed.
Abstract
Aims: To follow the variation of some biological and biochemical parameters in HIV-infected patients under antiretroviral treatment at the Maradi Regional Hospital.
Study Design: Retrospective and prospective study
Study Location and Duration: Maradi Regional Hospital; from August 2021 to April 2021, a duration of 9 months.
Methodology: We followed the variation of some immunological and biochemical parameters in patients living with HIV, evaluated the CD4+ T cell counts, the viral load, the leukocyte count, and carried out the measurement of haemoglobin, glycaemia, creatinemia, and ALAT levels in the blood at the follow-up visits (month 0 (M0), month 3 (M3), and month 6 (M6)), except for the viral load and CD4+ T-cell counts, which were measured at M0 and M6, and the HBsAg test at M0.
Results: 99 patients were included in this study. The sex ratio was 2.6 in favour of females. At enrolment, 63.6% of patients had a CD4+ T-cell count < 200/mm³, 56.6% had anaemia, 40.4% had hypoglycaemia and there was a significant increase in patients with an undetectable viral load from enrolment to the last visit at M6. At the end of the study, we observed an improvement in CD4+ T-cell counts, haemoglobin, glycaemia and viral load at each subsequent visit. We did not observe any significant evolution of creatinemia and alanine aminotransferase rate.
Conclusion: At the end of the study, we observed an improvement in CD4+ T-cell count, glycaemia, haemoglobin and viral load. We did not observe any particular change in the biochemical parameters of creatinemia and ALAT levels. This shows the non-toxicity of the antiretroviral treatments. Finally, we observed some difficulties in our study which deserve to be improved.
Keywords: HIV, CD4, anaemia, maradi, Niger
How to Cite
References
Abdel Hameed MR, Nafady HA, Mostafa MI, Sayed D, Obiedallah AA. Possible role of CD11a in primary immune thrombocytopenia patients on immunosuppressive therapy. J Blood Med. 2021;12:197-205.
Available :https://doi.org/10.2147/JBM.S300717
Xue W, Zhang Y, Wang H, Zhang Y, Hu X. Multicenter study of controlling nutritional status (CONUT) score as a prognostic factor in patients with HIV-related renal cell carcinoma. Frontiers in Immunology. 2021;12.
DOI: 10.3389/fimmu.2021.778746.778746
Abdel Hammed MR, Elgendy SG, El-Mokhtar MA, Sayed D, Mansour SM, Darwish AM. T-lymphocytes expression of toll-like receptors 2 and 4 in acute myeloid leukemia patients with invasive fungal infections. Mediterr J Hematol Infect Dis. 2022;14(1):e2022022. PMID : 35444773 ; PMCID : PMC8992612. DOI: 10.4084/MJHID.2022.022.
Hernández JC, Stevenson M, Latz E, Urcuqui-Inchima S. HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. AIDS Res Hum Retroviruses. 2012;28(10):1313-28.
Epub 2012 Mar 12. PMID: 22280204; PMCID: PMC3482876. DOI: 10.1089/aid.2011.0297.
Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32(1):23-63. v32.i1.30. PMID: 22428854; PMCID: PMC3410706. DOI: 10.1615/critrevimmunol.
Stylianou E, Aukrust P, Kvale D, Müller F, Frøland SS. IL-10 in HIV infection: increasing serum IL-10 levels with disease progression--down-regulatory effect of potent anti-retroviral therapy. Clin Exp Immunol. 1999;116(1):115-20. x. PMID: 10209514; PMCID: PMC1905221. DOI: 10.1046/j.1365-2249.1999.00865.
Syed SS, Balluz RS, Kabagambe EK, Meyer WA 3rd, Lukas S, Wilson CM, Kapogiannis BG, Nachman SA, Sleasman JW. Assessment of biomarkers of cardiovascular risk among HIV type 1-infected adolescents: role of soluble vascular cell adhesion molecule as an early indicator of endothelial inflammation. AIDS Res Hum Retroviruses. 2013; 29(3):493-500. Epub 2012 Dec 3. PMID: 23062187; PMCID: PMC3581064. DOI: 10.1089/AID.2012.0086.
Milošević N, Rütter M, David A. Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines. Front Med Technol. 2022;4:846065. PMID: 35463298; PMCID: PMC9021548. DOI: 10.3389/fmedt.2022.846065.
Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020;10(3):727-742. PMID: 32266087; PMCID: PMC7136921.
Porichis F, Kaufmann DE. Role of PD-1 in HIV pathogenesis and as target for therapy. Curr HIV/AIDS Rep. 2012;9(1):81-90. PMID: 22198819; PMCID: PMC3731769. DOI: 10.1007/s11904-011-0106-4.
Cherabi K, Faucher JM, Landman R. HIV infection and AIDS. 1998th ed. (HIV/AIDS). 1998 ;272.
World Health Organization. Main landmarks on HIV/AIDS [Internet] ; 2021.
Available: https://www.who.int/en/news-room/fact-sheets/detail/hiv-aids
[Accessed on : 2022 Jan 9].
Abdoulaye O, Harouna Amadou ML, Biraima A, Amadou O, Doutchi M, Alhousseyni Maiga D et al. Frequency of tuberculosis and the impact of immunosuppression in people living with HIV (PLHIV) followed at the regional hospital center of Maradi, Niger. Mali medical. 2021;36(3):20-23.
Derep Veltomtoh L. Evaluation of the nutritional status of PLHIV hospitalized in the infectious diseases department [Pharmacy thesis]. USTTB; 2021.
Diallo K, Wembulua BS, Sarr G, Badiane A, Pudence BBN, Diatta A, Coumé M, et al. HIV infection in the elderly: epidemiological and clinical profile in the region of Ziguinchor in southern Senegal. RAFMI. 2021;8(1):19-24.
Meminta B. Dynamics of some biological parameters in patients on antiretroviral treatment at the somine dolo hospital in MOPTI [Pharmacy thesis]. USTTB; 2014.
Bedji Tchenin L. Evaluation of micronutrients (vitamins A, E), hematological and biochemical profiles in people living with human immunodeficiency virus [functional and molecular biology]. Felix Houphouët Boigny University; 2014.
Lozès E, Ahoussinou C, Agassounon Tchibozo Djikpo M, Dahouegnon E, Ahossouhe N. Variability of CD4 lymphocyte count and viral load in people living with HIV on antiretroviral treatment: case of Saint Jean De Dieu hospital in Tanguieta (Benin). Int J Biol Chem Sci. 2012;6(2):650‑6.
Diallo Cheickna M. Late HIV screening in the delivery room at the Fousseyni Daou hospital in Kayes : clinical and epidemiological aspects [medical thesis]. USTTB; 2019.
Makougoum Njidie CF. Cardiovascular damage during HIV : epidemio-clinical aspects [medical thesis]. University of Sciences, Techniques and Technologies of Bamako; 2021.
Kante AS, Diakite M, D Kaba, Ly BM, Dembélé DT, Sako FB. Blood count abnormality in people living with HIV in the oncology hematology department of the Donka National Hospital. Jaccr Africa. 2020;4(4):99-103.
Djibrilla Almoustapha A, Chefou M, Maman Brah M, Moussa Ounteini A, Brah S, Daou M et al. Blood count abnormalities correlated with CD4 count in HIV-positive subjects followed at the Ambulatory Treatment Center (CTA) in Niamey. J. Rech. Science. Univ. Lome (Togo). 2020; 22(1-2):229-235.
Karfo R, Kabré E, Coulibaly L, Diatto G, Sakandé J, Sangaré L. Evolution of biochemical and hematological parameters in people living with HIV/AIDS on antiretroviral treatment at the Medical Center of Camp General Aboubacar Sangoule Lamizana. Pan Afr Med J. English. 2018;29:159.
PMID : 30050623 ; PMCID : PMC6057560. DOI: 10.11604/pamj.2018.29.159.13659.
Kalimira Kachelewa B, Lunjwire Mulemangabo PP, Kyambikwa Bisangamo C. Elevated transaminases and associated factors in people living with HIV - AIDS (PLHIV) at the PHARMAKINA - BUKAVU Ambulatory Treatment Center (CTA). International Journal of Innovation and Scientific Research. 2016;26(1):341-46.
Dollo MD. Evolution of plasma viral load and TCD4 lymphocyte level in a cohort of 930 patients on ARVs followed over 18 months at the Private ALGI laboratory in Bamako (Mali). [Pharmacy thesis]. University of Bamako; 2011.