Etiologies and Associated Factors Death Among People Living with the Human Immunodeficiency Virus (PLHIV) Hospitalized for Febrile Consciousness Disorders in the Infectious and Tropical Diseases Departmentof the Donka National Hospital, Guinea

Mamadou Oury Safiatou DIALLO *

Department of Infectious and Tropical Diseases, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University of Conakry, Guinea.

Ibrahima BAH

Department of Infectious and Tropical Diseases, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University of Conakry, Guinea.

Karamba SYLLA

Department of Infectious and Tropical Diseases, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University of Conakry, Guinea.

Amadou Daye DIALLO

Department of Infectious and Tropical Diseases, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University of Conakry, Guinea.

Fodé Bangaly SAKO

Department of Infectious and Tropical Diseases, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University of Conakry, Guinea.

Mamadou Saliou SOW

Department of Infectious and Tropical Diseases, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University of Conakry, Guinea and Center for Research and Training in Infectiology of Guinea (CERFIG), Guinea.

*Author to whom correspondence should be addressed.


Abstract

Introduction: Central nervous system (CNS) damage is common duringhuman immunodeficiency virus (HIV) infectionand occur in cases of immunosuppression, which leads to altered consciousness. The objective of this work was to identify the etiologies and factors associated with the death ofPLHIVhospitalized for febrile consciousness disorders in the infectious and tropical diseases departmentfrom Donka National Hospital.

Methodology: This was a retrospective study of descriptive and analytical type over five (5) years in the infectious and tropical diseases department of the Donka National Hospital. Included in this study werePLHIV under treatment antiretroviraL(ART)or not, aged over 15, hospitalized in the infectious diseases department of Donka National Hospital. for febrile consciousness disorders or those who developed it during the study period.

The parameters studied were sociodemographic characteristics, clinical picture, clinical staging of HIV/Acquired Immuno-Deficiency Syndrome(AIDS) according tothe World Health Organization(WHO).

Factors associated with deaths were searched from logistic regression in multivariate analysis and all variables with a value of P˂0.05 were considered statistically significant.

Results: Two hundred and five out of five hundred and thirty-four (205/534) files ofPLHIV, hospitalized for febrile consciousness disorderswere sampled and enrolled for this studyi.e. a prevalence of 38.39%. The average age of the patients was 42.28 ± 12.54 years with a sex ratio of 0.97. Cerebral toxoplasmosis was the most common etiology.Severe immunosuppression was one of the factors statistically associated with death.           

Conclusion: Febrile consciousness disorders remain very common, with multiple etiologies inPLHIV. The CD4 count ≤ 200 cells/mm3, the depth of the coma and the absence of antiretroviral treatment were the factors associated with death.

Keywords: Consciousness Disorders, fever, PvHIV, etiologies, death, Donka, guinea


How to Cite

DIALLO, Mamadou Oury Safiatou, Ibrahima BAH, Karamba SYLLA, Amadou Daye DIALLO, Fodé Bangaly SAKO, and Mamadou Saliou SOW. 2024. “Etiologies and Associated Factors Death Among People Living With the Human Immunodeficiency Virus (PLHIV) Hospitalized for Febrile Consciousness Disorders in the Infectious and Tropical Diseases Departmentof the Donka National Hospital, Guinea”. Asian Journal of Research in Infectious Diseases 15 (10):7-15. https://doi.org/10.9734/ajrid/2024/v15i10377.