Asian Journal of Research in Infectious Diseases 2020-08-08T21:12:31+00:00 Asian Journal of Research in Infectious Diseases Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Infectious Diseases (ISSN: 2582-3221)&nbsp;</strong>aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRID/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of&nbsp;‘Infectious Diseases’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Assessing Meteorological Variables, Larvae Free Rate and Dengue Incidence in Yogyakarta, Indonesia 2020-08-08T21:12:31+00:00 Juhrati Raodatul Zannah Sulistyawati Sulistyawati <p><strong>Aims:</strong> Dengue is a disease closely related to the environment, including several climatic variables such as temperature, humidity, and wind speed. This research attempted to illustrate the relationship between dengue fever incidence and climatic factors, larva free rate (LFR) or Angka Bebas Jentik (ABJ) in Yogyakarta city, Indonesia.</p> <p><strong>Methodology:</strong> Secondary data from meteorological agency and district health office were collected and analyzed using Spearman Rank Test and Multiple Linear Regression Test.</p> <p><strong>Results:</strong> Temperature, air humidity and wind speed were associated with dengue incidence in Yogyakarta city during 2016-2018. Correlation between rainfall and dengue was r = 0.27 and p value = 0.11; temperature and dengue r =0.62 and p value = 0.000; humidity and dengue r=0.38 and p value 0.02; wind speed and dengue r=-0.36 and p value = 0.03; r = -0.36. Larvae free rate and dengue r=0.04 and p value = 0.77.</p> <p><strong>Conclusion:</strong> Climate variables are an important factor affecting the incidence of dengue fever. To decrease the incidence, it is necessary to educate the community on improving awareness related to the mosquito breeding place.</p> 2020-08-03T00:00:00+00:00 ##submission.copyrightStatement## Evaluation of Phytochemicals of Cassia occidentalis L. for their Binding Affinities to SARS-CoV-2 3C-Like Protease: An in Silico Approach 2020-08-07T09:19:36+00:00 Tohmina Afroze Bondhon Md. Aynal Haque Rana Anamul Hasan Rownak Jahan Khoshnur Jannat Mohammed Rahmatullah <p><strong>Aims: </strong>Corona virus SARS-CoV-2, otherwise known as COVID-19 has created a pandemic resulting in social and financial crisis throughout the world. The virus has no known drugs or vaccines for preventive or therapeutic purposes. The objective of the present study was to screen phytochemicals from <em>Cassia occidentalis</em> L. in virtual screening (<em>in silico</em>) studies to evaluate their potential of binding to the main 3C-like protease of the virus and so stop its replication.</p> <p><strong>Study Design: </strong>Molecular docking approach was used for virtual screening studies.</p> <p><strong>Place and Duration of Study:</strong> University of Development Alternative between April and July 2020.</p> <p><strong>Methodology:</strong> Molecular docking (blind) were done with the help of Autodock Vina. We have used the pdb file (6LU7) of the main protease of SARS-CoV-2 3C-like protease or SARS-CoV-2 3CL<sup>pro</sup> (monomeric form) to study binding of the phytochemicals.</p> <p><strong>Results:</strong> Of the nine phytochemicals studied, the C-glycosidic flavonoids, cassiaoccidentalins A-C demonstrated excellent binding affinities to the protease. The compounds bound to the active site of the protease with binding energy values of -8.2 to-8.4 kcal/mol.</p> <p><strong>Conclusion:</strong> The <em>in silico</em> studies suggest that the compounds merit actual COVID-19 inhibitory tests and have potential for anti-COVID-19 use.</p> 2020-08-07T00:00:00+00:00 ##submission.copyrightStatement##