Open Access Original Research Article

Evaluation of Knowledge of MDR-TB among Medicine Training Doctors in Tertiary Care Hospital, Karachi, Pakistan

Afifa Saulat, Anwar Nabeel Jafri

Asian Journal of Research in Infectious Diseases, Page 1-7
DOI: 10.9734/ajrid/2020/v5i230161

Tuberculosis is the oldest documented infectious diseases in humans and they still cause significant morbidity and mortality. Multi-Drug Resistant Tuberculosis (MDR-TB) is a growing hazard to human health worldwide and threat to control of tuberculosis. WHO estimates 3.2% incidence of MDR TB in new cases. MDR-TB new cases are created each year by a combination of poor patient compliance with treatment and physician error. The purpose of the study is to determine the status of knowledge and awareness amongst the medicine resident about the very basic knowledge of MDR-TB and need to strengthen teaching about tuberculosis to postgraduates so the objective of the study is to determine the frequency of knowledge of MDR –TB among medicine residents (postgraduate trainees) at a tertiary health care hospital Karachi. It is a descriptive based cross sectional study. 58 post graduates trainees were included. A simple questionnaire about MDR-TB was asked to fill in 30 minutes, each correct response will be given 10 marks and those who score 70% will be labeled as knowledgeable. The primary outcome measure was the frequency of knowledge of MDR –TB among medicine residents (postgraduate trainees) at a tertiary health care which turned out to be 65.5% knowledge among postgraduate trainees. So we concluded that there is a need of further studies with larger sample size and follow up studies after educating the trainees more of senior levels so that identification of predictors of mortality, so as to timely diagnose, intervene and hence prevent morbidity and fatalities. It is, therefore, important to develop continuous health education to improve TB knowledge and awareness at different levels.

Open Access Original Research Article

Detection of Serum IgG Antibodies against Mycobacterium tuberculosis among University Athletes in Rivers State, Nigeria

T. I. Cookey, S. Adewuyi- Oseni, I. O. Okonko, K. C. Anugweje

Asian Journal of Research in Infectious Diseases, Page 8-13
DOI: 10.9734/ajrid/2020/v5i230162

Aim: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, is a strictly aerobic bacterium that grows fastidiously and slow, which is among the top 10 causes of death globally and the leading cause from a single infectious agent (above HIV/AIDS). Among the deadly diseases ravaging the world, tuberculosis remains one of the commonest and deadliest. The objective of this study is to determine the prevalence of tuberculosis (TB) among the athletes of the University of Port Harcourt (UNIPORT), Rivers State, Nigeria.

Study Design:  Cross-sectional study.

Place and Duration of Study: Sports Institute, University of Port Harcourt (UNIPORT), Nigeria, between June 2012 and July 2015.

Methods: A total of 100 university athletes (51 males and 49 females, the age ranged from 15-47 years) was recruited for this study. Blood samples were collected from the athletes and analyzed for serum IgG antibodies against Mycobacterium tuberculosis. OneStep Tuberculosis (TB) rapid test was used for the detection of TB antibody (Isotypes IgG, IgM and IgA) in whole blood samples from the subjects. Commercially available ELISA based kits (manufactured by Dia.Pro, Milano, Italy) were also used.

Results: The seropositivity of TB among the athletes was 5.0%. The result of the study showed that male athletes had a higher prevalence of tuberculosis than their female counterpart (5.9% vs 4.1%). Subsequently, the age groups 15-25 years had a higher prevalence of tuberculosis (6.5%) compared to age groups 26 years and above (2.6%). A significant association existed between the athletes' ages and TB prevalence (p= 0.035) and none existed with gender (p=0.654).

Conclusion: This study confirms the presence of Mycobacterium tuberculosis-specific antibodies among university athletes. Strict surveillance of the diseases is highly recommended to curb its spread and the potential increase in Multidrug-resistance tuberculosis (MDR-TB) and Extensively drug-resistance Tuberculosis (XDR-TB) as it is highly contagious.

Open Access Original Research Article

Nanoinsecticidal Efficacy of Ag/Ni Bimetallic Nanoparticles (BMNPs) on Lymphatic Filariasis Vector

Danbature Wilson Lamayi, Ezra Abba, Zaccheus Shehu, Muhammad Mustapha Adam

Asian Journal of Research in Infectious Diseases, Page 14-21
DOI: 10.9734/ajrid/2020/v5i230163

Aims: Nanoparticles are gradually gaining wide scientific interest due to their various applications in catalysis, magnetism, medicine, optics, as antibacterial and nanolarvicidal agents. This research aimed at evaluating the larvicidal activity of green synthesized Ag/Ni BMNPs from the aqueous root extract of Borassus aethiopum as the stabilizing agent as well as their spectroscopic investigation using UV-Visible and FT-IR spectroscopy.

Place and Duration of Study: The study was conducted in Gombe State University between August and December, 2019.

Methodology: In this study, Ag/Ni hybrid bimetallic nanoparticles was synthesized using an eco-friendly method from the secondary metabolites of Borassus aethiopum acting as the reducing agent.

Results: Optical measurements using UV-Vis showed the maximum absorption wavelength at 410nm while the FT-IR result for the root extract showed peaks at 3443.26cm-1, 2929.48 cm-1, 1651.28 cm-1, and 1080.12 cm-1 corresponding to OH stretch, sp3 C-H stretch, C=C stretch and C-O-C stretching respectively. These were replaced in the spectra of the BMNPs with the absence and appearance of some others indicating that they were involved in the capping process. The lethal concentration (LC50) was found to be 5.730, 13.585 and 15.735 mg/L for 1st, 2nd and 3rd/4th instars respectively. Also, the lethal concentration (LC90) was found to be 88.444, 195.689 and 236.889 mg/L for 1st, 2nd and 3rd/4th instars respectively.

Conclusion: The larvicidal bioassay result showed a dose-dependent mortality rates against Culex quinquefasciatus larvae which suggest they can be developed to control the insect population.

Open Access Original Research Article

Evaluation of EWMA Control Charts for Monitoring Spread of Transformed Observations of COVID-19 in India

Brijesh P. Singh, Madhusudan J. V., Abhay Kumar Tiwari, Sandeep Singh, Utpal Dhar Das

Asian Journal of Research in Infectious Diseases, Page 25-36
DOI: 10.9734/ajrid/2020/v5i230165

COVID-19 a pandemic due to novel corona virus emerged from Wuhan, China in December 2019 and now the whole world facing its threat. This is a disaster pandemic for  almost every nation on the earth. Such novel corona virus impacts on every country in  the world irrespective of race, ethnicity, environment and economic status. In this study, an attempt has been made to use statistical process control technique to understand spread of COVID-19 in some major states of India as well as India. Warning limits and control limits has been estimated and discussed for average weekly growth index of COVID-19 pandemic. Study indicates that there is no hope for controlling the  pandemic in near future because the average weekly growth index of COVID-19 pandemic is far from zero.

Open Access Letter to the Editor

Letter to the Editor: Neonatal Coronavirus Disease-2019: Presentation and Management

Ruma Parvin, A. H. M Khairul Bashar, Md Moshiur Rahman, Sheikh Farjana Sonia, Azmeri Sultana, K. M. Ziaur Rahman

Asian Journal of Research in Infectious Diseases, Page 22-24
DOI: 10.9734/ajrid/2020/v5i230164

The “Type of Article” of this paper is “Letter to the Editor”. This paper discuses about: “Letter to the Editor: Neonatal Coronavirus Disease-2019: Presentation and Management”. No formal abstract is available. Readers are requested to read the full article.